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\nKhatrimaza Hitman Agent 47 Full Movie In Hindi Dubbed (1-7-2017) in Hindi | Khatrimaza. Download Khatrimaza Hitman Agent 47 Full Movie In Hindi Dubbed (1-7-2017).Venlafaxine (N -[2-\\[(3,4-dimethyl-1-oxo-5-phenyl-1,2-dihydro-4-quinolinyl)carbonyl\\]amino]-2-imidazoline) is a serotonin and norepinephrine reuptake inhibitor that is chemically named (2S)-2-[[[1-(3,4-dimethylphenyl)-2-imidazolin-2-yl]methyl]amino]-3,3-diethylbutyramide, and is currently marketed as Effexor\u00ae. Effexor\u00ae is used in the treatment of depression and several neuropathic pain conditions.
\nIn U.S. Pat. Nos. 6,121,261, 6,172,810 and 6,011,155 all three of which are hereby incorporated by reference in their entirety, Effexor\u00ae is disclosed to be prepared using base-mediated reaction of 2-amino-3-ethyl-1,3-propanediol with methyl 2-cyanoacrylate (methyl 2-cyanoacrylate (MCA) is a highly reactive electrophile that is commercially available from a number of vendors, such as Aldrich Chemical Company, and is used to rapidly modify sulfhydryl or amine groups in peptides, proteins, antibodies, oligonucleotides, and small organic molecules. The 2-cyanoacrylate esterification is typically carried out in a solution with a base, such as sodium methoxide, followed by acidification.
\nIt would be desirable to find a base-mediated reaction scheme that facilitates the synthesis of venlafaxine and venlafaxine hydrochloride and
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