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Granulomatosis with polyangiitis (GPA) is a common autoimmune vasculitis, which presents primarily with multiorgan inflammatory disease that can affect the respiratory, cardiac, renal, and gastrointestinal systems. Neurological complications occur in about one-third of patients and are associated with a poor prognosis. We present a case series of nine patients who presented with neurological disease in association with GPA. The types of clinical manifestations and neurological complications seen are described. We propose that neuroradiology is a valuable diagnostic tool in the assessment of patients with GPA.Blackstone renames CSA as Public Safety Equipment Inc.

By Jason Cipriani

February 24, 2013

Retail giant and third-biggest institutional investor Blackstone has announced the renaming of its Carbon Steel Alliance (CSA) to Public Safety Equipment Inc. (PSE).

The new name and logo are intended to attract increased public awareness of the cause-related company. The change will take place

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Wnt/beta-catenin pathway is critical in embryogenesis, in the development of a variety of diseases and in the maintenance of stem cells. The pathway is deregulated in various cancers and affects gene transcription via modulation of a cascade of nuclear events including down-regulation of the expression of TCF/beta-catenin transcriptional repressors, up-regulation of target genes such as c-myc and survivin, and phosphorylation of beta-catenin. Conversely, in the absence of Wnt ligands, unphosphorylated beta-catenin is degraded via the ubiquitin-proteasome degradation system. Many studies have demonstrated that the activation of the Wnt/beta-catenin pathway and the accompanying up-regulation of target genes are important for the cell growth and angiogenesis in solid tumors. Using transgenic mice expressing Tcf4, beta-catenin and TCF-1, we analyzed the biological effects of the Wnt/beta-catenin pathway on angiogenesis and found that beta-catenin and TCF-1 promote endothelial tube formation, whereas their absence inhibits angiogenesis. These transgenic mice will provide useful tools to analyze the role of Wnt/beta-catenin pathway in angiogenesis.Make well-rounded resume

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