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Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China. To date, few studies have been conducted to evaluate the outcomes of NPC treatments. The purpose of the present study was to examine the survival and incidence of complication rates in NPC patients treated with a four-dimensional computed tomography (4D-CT)-based conformal radiotherapy technique. From January 2007 to June 2009, 64 previously untreated patients with NPC received a 4D-CT-based conformal treatment with an Intensity-Modulated Radiation Therapy (IMRT) technique. After a 4D-CT was completed, both the patient’s tumor and internal anatomy were moved to a treatment position. Tumor and normal tissue movement information from the 4D-CT was used for target delineation. The gross tumor volume (GTV), cervical lymph node (LN) and clinical target volume (CTV) structures were defined and contoured on each 4D-CT. The corresponding treatment planning volume (PTV) was generated by summation of GTV, LN and CTV. Target motion and setup error were also calculated. The overall survival rates (OS) at 1, 2, 3, and 4 years were 86.5%, 73.3%, 63.6%, and 58.6%, respectively. Forty patients (62.5%) relapsed at 6 months. The 1, 2, 3, and 4 years locoregional relapse-free survival (LRFS) rates were 85.6%, 74.2%, 62.1%, and 59.8%, respectively. The 2-year distant metastasis-free survival (DMFS) rates were 77.5%. Among the 53 patients with tumors >2.5 cm(3) in volume, the 2-year disease-free survival (DFS) and OS rates were 76.8% and 87.6%, respectively. Conversely, the DFS and OS rates in patients with tumors ≤2.5 cm(3) were 100% and 87.5%, respectively. The difference was statistically significant (P = 0.039). The 3-year local and regional control rates
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