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Campbell Public School Global History. Introduction It was a long time ago (2002) but I would like to think that this was my first rough attempt to place in history.Influence of antidepressant drugs and endogenous beta-endorphin on analgesic effect of codeine in mice.
The effects of opiates and antidepressants on the analgesic effect of codeine (COD) were investigated by evaluating the number of writhing in mice and the analgetic effect of this drug in rats. The analgesic effect of COD was antagonized by naloxone, whereas the analgesic effect of morphine was not affected by beta-endorphin (beta-end.). The antidepressant drugs (trazodone and imipramine) antagonized the analgesic effect of codeine but not of morphine. The effect of these drugs on the analgesic effect of morphine was not changed after the pretreatment with beta-end. The analgesic effect of the antidepressant drugs was antagonized in mice by naloxone but not by beta-end. The effect of these drugs on the analgesic effect of codeine was antagonized in rats by naloxone but not by beta-end. These data suggest that the analgesic effect of codeine is affected by the endogenous beta-end. The analgesic effect of codeine and of morphine is not affected by the endogenous beta-end. In contrast, the analgesic effect of antidepressants is dependent on the endogenous beta-end. In vitro, in mice brain, beta-end. did not alter the binding affinity of codeine for the mu-receptor or for the N-methyl-D-aspartic acid (NMDA) receptor. These data would explain the difference between codeine and morphine in their antinociceptive effect. beta-end. is at presynaptic level and does not modify morphine antinociceptive effect, but modifies the analgesic effect of codeine by the action of dopamine.Q:
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BIID’s inclusive approach ensures serving the poor in a sustainable way . For the first time, the impact of economic and urban development on. Solving problems related to urban planning and design in cities in developing countries.. of the city, business owners and public and private. for sustainable urban development and inclusive green cities.
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